Star and monster of the Cult Classic Slither Brenda James started out as a 1980s commercial actress in Los Angeles She was cast as a regular in one of the very first cable sitcoms Safe at Home for Ted Turners network Brenda spent decades either in guest star roles like the pregnant murderer in The Practice or screaming in slasher movies like Cutting Class where she starred along with Brad Pitt in his first feature Not only did Brenda James play the Brenda Blob for James Gunn but she worked in the MTV boy band series 2Gether as sleazy manager Liz Porter produced and written by Brian Gunn and Mark Gunn Touring Europe as Agnes in Agnes of God was one of her career highlights as well as being the inspiration in Patriot Games for Harrison Ford to bring back a crucial memory that twists the plot for the entire movie conclusion The 2000s brought Brenda James into the scifi genre where she played Dr Katie Brown the horticultural love interest for David Hewletts character Rodney McKay She worked alongside Anthony Michael Hall and Ally Sheedy in the Breakfast Club themed cliff hanger episodes of The Dead Zone